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Calb1tm2.1(cre)Hze - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Calb1tm2.1(cre)Hze
calbindin 1; targeted mutation 2.1, Hongkui Zeng 		Driver: Calb1
Type: Targeted (Recombinase)
Synonym: Calb1-IRES2-Cre-D, CBCre
Molecular description: The targeting vector contains, from 5' to 3', an FRT3 site within Calb1 intron 10, a partial Calb1 exon 11 sequence up to and including the endogenous stop codon,an IRES2 sequence, Cre recombinase, a polyA sequence, an AttB site, a PGK-Neomycin cassette, an FRT5 site, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 late polyA signal, and an AttP site. PhiC31-mediated recombination removed the AttB/AttP-flanked sequence (PGK-Neo-polyA::FRT5::RNA splice acceptor::3'hygro-polyA) and replaced it with the recombined AttB/AttP site (AttL). Mice have both endogenous gene and Cre recombinase expression directed to calbindin 1-expressing cells by the endogenous promoter/enhancer elements of the Calb1 locus.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 22 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory