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Chattm2(cre)Lowl - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Chattm2(cre)Lowl
choline acetyltransferase; targeted mutation 2, Bradford B Lowell 		Driver: Chat
Type: Targeted (Recombinase)
Synonym: ChAT-IRES-Cre
Molecular description: An optimized internal ribosome entry sequence (IRES) fused to cre recombinase followed by a neomycin resistance cassette flanked FRT sites was inserted after the ChAT stop codon in BAC (bMQ185k21) using homologous recombination in bacteria. A genomic ChAT fragment with 4kb homology arms on either side of the IRES-Cre insertion site was lifted out from the BAC using reverse recombineering techniques and transformed into ES cells. This allele was used to generate Chattm1(cre)Lowl.
Find mice (IMSR): Mouse Strains: 4 strains available       Cell Lines: 0 lines available
Additional Tissues: Chattm2(cre)Lowl activity also observed in:
alimentary system, head, integumental system, muscle, renal & urinary system, reproductive system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:184579 Full Image
Fig. Chat Brain 1 P56 J:184579 Full Image
Fig. Chat Brain 1 P7 J:184579 Full Image
Fig. Chat Brain 2 P56 J:184579 Full Image
Fig. Chat Brain 2 P7 J:184579 Full Image
Fig. Chat Embryo 1 E15.5 J:184579 Full Image
Fig. Chat Embryo 2 E15.5 J:184579 Full Image
Fig. Chat Periph nerve P56 J:184579 Full Image
Fig. Chat Periph Nerve P7
J:184579 Full Image
Fig. Chat Sp Cord 1 P56 J:184579 Full Image
Fig. Chat Sp Cord 1 P7 J:184579 Full Image
Fig. Chat Sp Cord 2 P56 J:184579 Full Image
Fig. Chat Sp Cord 2 P7 J:283278 Fig. 1 J:283549 Fig. 1 J:331457 Fig. 6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 278 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory