Cx3cr1<tm2.1(cre/ERT2)Litt> - Cardiovascular System Recombinase Activity Detail MGI Mouse

Cx3cr1^{tm2.1(cre/ERT2)Litt} - Cardiovascular System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Cx3cr1^{tm2.1(cre/ERT2)Litt}
C-X3-C motif chemokine receptor 1; targeted mutation 2.1, Dan R Littman

Driver: Cx3cr1
Type: Targeted (Inducible, Recombinase, Reporter)

Inducer:

tamoxifen

Synonym:

Cx3cr1^CreER, CX3CR1^YFP-creER

Molecular description:

A targeting vector was designed to replace exon 2 of the chemokine (C-X3-C) receptor 1 (Cx3cr1) gene with a cre/ERT2 (cre recombinase fused to an estrogen receptor ligand binding domain) coding sequence, followed by an internal ribosome entry site (IRES) and an enhanced yellow fluorescent protein (EYFP). A frt-flanked neomycin resistance cassette, in reverse orientation to the gene, was also inserted downstream of the EYFP sequence. Flp-mediated recombination excised the neomycin resistance sequence.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Cx3cr1^{tm2.1(cre/ERT2)Litt} activity also observed in:

head, hemolymphoid system, integumental system, nervous system ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

209 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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