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Tg(ACTA1-cre/Esr1*)2Kesr - Head
Recombinase Activity Detail
Allele Information
Allele:
Tg(ACTA1-cre/Esr1*)2Kesr
transgene insertion 2, Karyn A Esser 		Driver: ACTA1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: HSA-Cre, HSA-MCM, HSA-MerCreMer
Molecular description: The human alpha-skeletal actin gene promoter (ACTA1; HSA) was cloned into a vector upstream the cre recombinase gene fused at the N- and C-termini to mutated estrogen receptor ligand-binding domains (MerCreMer). A beta-globin intron II sequence followed by a polyadenylation sequence was inserted downstream of the promoter to ensure proper splicing. The construct was injected into B6C3F2 embryos. Five founders were generated and crossed to Rosa-lacz reporter mice to assess germline transmission and inducible muscle-specific recombinase activity. Line 2 was established.
Find mice (IMSR): Mouse Strains: 2 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(ACTA1-cre/Esr1*)2Kesr activity also observed in:
cardiovascular system, cavities & their linings, limbs, muscle, sensory organs
Tissue Information
Head Other recombinase alleles with activity in Head tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 70 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory