Tg(Col11a2-cre)4Nhzi - Cardiovascular System Recombinase Activity Detail MGI Mouse

Tg(Col11a2-cre)4Nhzi - Cardiovascular System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Col11a2-cre)4Nhzi
transgene insertion 4, Nobumichi Hozumi

Driver: Col11a2
Type: Transgenic (Recombinase)

Synonym:

alpha2(XI) collagen-Cre line #4

Molecular description:

Cre recombinase replaced the beta-galactosidase gene in a construct containing the -742bp Col11a2 promoter sequence, SV40 RNA splice site, lacZ sequence, and Col11a2 first intron. The 4.2 kb construct was microinjected into fertilized pronuclei. 5 founders were obtained. 2 lines (1 and 5) did show recombination in crosses to lacZ reporter mice. Line 2 showed cre activity in neural tissue and line 3 had ubiquitous activity. Line 4 was chosen due to its restricted cre activity pattern, although it had a low transgene copy number compared to the other lines.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Tg(Col11a2-cre)4Nhzi activity also observed in:
embryo-other, head, limbs, mesenchyme, mouse-other, skeletal system

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

1 reference(s)

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