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Tg(Nes-phiC31*)1Imayo - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nes-phiC31*)1Imayo
transgene insertion 1, Itaru Imayoshi
Driver: Nes
Type: Transgenic (Cre/Flp)
Synonym: Nestin-PhiC31o
Molecular description: The construct was composed of a 5.8 kb fragment of the nestin promoter upstream of the sequence for optimized phiC31 recombinase (phiC31*), with the 1.8 kb second intron containing the neural stem/progenitor cell-specific enhancer downstream of the recombinase sequence. The SV40 polyadenylation sequence was also cloned into the vector. The linearized, purified construct was injected into pronuclei of fertilized one-cell embyros. Only one founder line was established. Mice show wide expression of phiC31 mRNA in the nervous system with no expression observed in non-neural tissues like somites. High expression is observed in the ventricular zone of the developing nervous system.
Find mice (IMSR): Mouse Strains: 1 lines available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nes-phiC31*)1Imayo activity also observed in:
sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory