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Runx1tm2.1(cre/Esr1*)Ims - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Runx1tm2.1(cre/Esr1*)Ims
runt related transcription factor 1; targeted mutation 2.1, Igor M Samokhvalov
Driver: Runx1
Type: Targeted (Inducible, Recombinase)
Inducer: induced by tamoxifen
Synonym: Runx1SACRE
Molecular description: A targeting vector was composed of the sequence for a tamoxifen-inducible cre recombinase (flanked by two mutated estrogen receptors, MerCreMer) with the Engrailed-2 splice acceptor (En2SA) sequence preceding the coding region and a transcription STOP sequence followed the cre/Esr1*. A floxed neo selection cassette followed the STOP. Insertion of the En2SA sequence prevents splicing of the STOP out and disrupted Runx1 expression from both the proximal P2 and distal P1 promoters. The neo was subsequently deleted from the allele.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Runx1tm2.1(cre/Esr1*)Ims activity also observed in:
embryo-other, extraembryonic component, hemolymphoid system, reproductive system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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J:182232 Fig. 3A E10.5 J:182232 Fig. 3A E8.5 J:182232 Fig. 3A E9.5
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory