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Nkx2-1tm1.1(cre/ERT2)Zjh - Nervous System
Recombinase Activity Detail
Allele Information
NK2 homeobox 1; targeted mutation 1.1, Z Josh Huang
Driver: Nkx2-1
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Nkx2.1-CreER
Molecular description: A targeting vector was designed to insert a CreERT2 fusion gene , an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the NK2 homeobox 1 locus (Nkx2-1). This construct was electroporated into embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with C57BL/6 mice to originate the colony. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to remove the neo selection cassette. These Nkx2.1-CreER (or Nkx2.1-CreERT2) mice were subsequently bred to C57BL/6 inbred mice for a few additional generations (and the FLPe transgene was removed).
Collection: Neuroscience Blueprint cre
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Nkx2-1tm1.1(cre/ERT2)Zjh activity also observed in:
alimentary system, endocrine system, respiratory system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
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J:216865 Full image
Fig. Nkx2-1 Adult Hypothalamus
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory