About   Help   FAQ
Dlx1tm1(cre/ERT2)Zjh - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Dlx1tm1(cre/ERT2)Zjh
distal-less homeobox 1; transgene insertion 1, Z Josh Huang 		Driver: Dlx1
Type: Targeted (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Dlx1-CreER, Dlx1-CreER-KI, Dlx1-CreERT2, Dlx1-CreERT2-KI
Molecular description: A targeting vector was designed to insert a CreERT2 fusion gene, an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the distal-less homeobox 1 locus (Dlx1). The construct was electroporated into (C57BL/6 x 129S4Sv/Jae)-derived V6.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with C57BL/6 mice to originate the colony. The mutation is predicted to result in a null allele. Tamoxifen-inducible Cre recombinase activity recapitulates the endogenous Dlx1 expression pattern, Following tamoxifen administration, Cre recombinase activity is observed in Dlx1 positive cortical GABAergic neurons, striatal neurons, and olfactory neurons.
Collection: Neuroscience Blueprint cre
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Dlx1tm1(cre/ERT2)Zjh activity also observed in:
head
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
References
All for this allele: 12 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory