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Ccktm1.1(cre)Zjh - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Ccktm1.1(cre)Zjh
cholecystokinin; targeted mutation 1.1, Z Josh Huang 		Driver: Cck
Type: Targeted (knock-in)
Synonym: Cck-IRES-Cre
Molecular description: A targeting vector was designed to insert an internal ribosome entry site (IRES), a cre recombinase sequence, a polyA sequence, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the cholecystokinin locus (Cck). This construct was electroporated into C57BL/6;129 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric males were bred with Actin-FLPe females (on a C57BL/6 congenic background) to achieve germline transmission and to remove the neo selection cassette. The resulting pups harboring the cre targeted mutation were selected. These Cck-IRES-Cre mice were subsequently bred together for several generations (and the FLPe transgene was removed).
Find mice (IMSR): Mouse Strains: 1 lines available       Cell Lines: 0 lines available
Additional Tissues: Ccktm1.1(cre)Zjh activity also observed in:
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Images
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J:184579
Fig. Cck Adrenal Adult J:184579
Fig. Cck Adrenal P7 J:184579
Fig. Cck Embryo1 E15.5 J:184579
Fig. Cck Embryo2 E15.5 J:184579
Fig. Cck Pancreas Adult J:184579
Fig. Cck Pancreas (female) P7 J:184579
Fig. Cck Pancreas (male) P7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/08/2013
MGI 5.13 		The Jackson Laboratory