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Allele Information
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Allele:
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Ccktm1.1(cre)Zjh
cholecystokinin;
targeted mutation 1.1, Z Josh Huang
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Driver: Cck
Type: Targeted (knock-in)
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Synonym:
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Cck-IRES-Cre
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Molecular description:
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A targeting vector was designed to insert an internal ribosome entry site (IRES), a cre recombinase sequence, a polyA sequence, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the cholecystokinin locus (Cck). This construct was electroporated into C57BL/6;129 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts. Chimeric males were bred with Actin-FLPe females (on a C57BL/6 congenic background) to achieve germline transmission and to remove the neo selection cassette. The resulting pups harboring the cre targeted mutation were selected. These Cck-IRES-Cre mice were subsequently bred together for several generations (and the FLPe transgene was removed).
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Find mice (IMSR):
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Mouse Strains:
1 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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Ccktm1.1(cre)Zjh activity also observed in:
adipose tissue,
alimentary system,
cavities and their linings,
endocrine system,
hemolymphoid system,
integumental system,
limbs,
liver and biliary system,
mesenchyme,
muscle,
nervous system,
renal and urinary system,
reproductive system,
respiratory system,
sensory organs,
skeletal system
(less)
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Tissue Information
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Cardiovascular System
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Other recombinase alleles with activity in Cardiovascular System tissues:
1700009P17Riktm1.1(icre)Heli,
Calb2tm1(cre)Zjh,
Crhtm1(cre)Zjh,
Eportm1(EGFP/cre)Uk,
Fgf16tm1.1(cre)Sms,
Foxa2tm2.1(cre/Esr1*)Moon,
Gad2tm2(cre)Zjh,
Gt(ROSA)26Sortm1.1(cre)Jphe,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Hcn4tm1(cre/ERT2)Anlu,
HhatTg(TFAP2A-cre)1Will,
Hprttm1(cre)Mnn,
Hsd11b2tm1(cre)Anft,
Isl1tm1(cre/Esr1*)Krc,
Isl1tm1(cre)Tmj,
Kdrtm1(cre)Sato,
Krt19tm1(cre)Mmt,
Lyz2tm1(cre)Ifo,
Mcm2tm1(cre/ERT2)Scpr,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Myf5tm3(cre)Sor,
Myl2tm1(cre)Krc,
Myocdtm1(cre)Jomm,
Nkx2-5tm1(cre)Rjs,
Nkx2-5tm2(cre)Rph,
Notch1tm3(cre)Rko,
Omptm4(cre)Mom,
Pax3tm1(cre)Joe,
Pitx2tm4(cre)Jfm,
Pvalbtm1(cre)Arbr,
Runx1tm1(cre/Esr1*)Ims,
Runx1tm2.1(cre/Esr1*)Ims,
Shhtm1(EGFP/cre)Cjt,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Ssttm2.1(cre)Zjh,
Taglntm1(cre/ERT2)Feil,
Taglntm2(cre)Yec,
Tbx1tm4(cre/Esr1*)Bld,
Tg(Acp5-cre)4Rda,
Tg(ACTA1-cre)79Jme,
Tg(ACTA2-cre)1Miwa,
Tg(Acta2-cre/ERT2)12Pcn,
Tg(Acta2-cre/ERT2)51Pcn,
Tg(ACTB-cre)1Tes,
Tg(ACTC1-cre)1Miwa,
Tg(ACTFLPe)9205Dym,
Tg(Acvrl1-cre)B1Spo,
Tg(Acvrl1-cre)L1Spo,
Tg(Akr1b7-cre)1Anm,
Tg(Alb1-cre)1Dlr,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(CAG-cre/Esr1*)86Lbgn,
Tg(Camk2a-cre)1Nobs,
Tg(CD2-cre)4Kio,
Tg(Cdh5-cre)1Nmoc,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)1Rha,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(Cga-cre)3Sac,
Tg(Chst4-cre)1Hkwa,
Tg(CMV-cre)1And,
Tg(CMV-cre)1Cgn,
Tg(Col1a2-cre)23Angl,
Tg(Col1a2-cre/ERT)7Cpd,
Tg(Col2a1-cre)1Asz,
Tg(COL2A1-cre)1Wag,
Tg(Col6a1-cre)1Gkl,
Tg(Csf1r-icre)1Jwp,
Tg(Csrp1-cre)1Sjc,
Tg(Cyp19a1-cre)5909Gle,
Tg(DBH-cre)9-9Koba,
Tg(Dbh-icre)1Gsc,
Tg(Dhh-cre)1Mejr,
Tg(Dll1-cre)33Dchp,
Tg(EIIa-cre)C5379Lmgd,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Frzb-cre)1Tylz,
Tg(Fzd9-cre)1Chzh,
Tg(Gata1-cre)1Sho,
Tg(GATA5-cre)1Krc,
Tg(GATA6-cre)#Jbeb,
Tg(GFAP-cre)25Mes,
Tg(Grik4-cre)G32-4Stl,
Tg(Hand2-cre)7-1Clou,
Tg(Hoxb2-cre)1Ksec,
Tg(Hsp70-1-cre)6Arge,
Tg(Hspa2-cre)1Eddy,
Tg(Ins2-cre)25Mgn,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kcne1-cre/ERT2)1Imos,
Tg(Kdr-cre)15962Brei,
Tg(Kdr-cre)15964Brei,
Tg(KRT14-cre)1Amc,
Tg(KRT14-cre/ERT)20Efu,
Tg(Leftb-cre)1Hmd,
Tg(Mbp-cre)9Gvn,
Tg(Mbp-cre,CAG-EGFP)53Masa,
Tg(Mef2c-cre)2Blk,
Tg(MMTV-cre)4Mam,
Tg(Mpz-cre)94Imeg,
Tg(Mx1-cre)1Cgn,
Tg(Mx1-cre)29-4Her,
Tg(Myh11-cre)5013Gko,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Myh11-cre/ERT2)1Soff,
Tg(Myh6-cre)2182Mds,
Tg(Myh6-cre/Esr1*)1Jmk,
Tg(Myh6-cre/PGR*)1Mds,
Tg(Myh6-cre/PGR*)6297Mds,
Tg(Myh7-cre)1Zli,
Tg(Myhc-cre)1Xya,
Tg(myl2-cre)1118Tmhn,
Tg(myl2-cre)1141Tmhn,
Tg(MYOD1-cre)M23Glh,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nkx2-5-cre)9Eno,
Tg(Nppa-cre)3Vmc,
Tg(Nppa-cre)4Vmc,
Tg(Osr1-cre)4Mrt,
Tg(Pax3-cre)1Joe,
Tg(Pcp2-cre)1Amc,
Tg(Pcp2-cre)2Mpin,
Tg(Pdgfb-icre/ERT2)1Frut,
Tg(Pf4-cre)Q3Rsko,
Tg(Plp1-cre/ERT)3Pop,
Tg(Postn-cre)1Sjc,
Tg(REN-cre)1Haca,
Tg(rtetR-tetO-cre)1Mhz,
Tg(S100b-cre)20Ito,
Tg(Sftpa1-cre)1Xya,
Tg(Sim1-cre)1Lowl,
Tg(Slco1c1-icre/ERT2)1Mrks,
Tg(Smad7-cre)1Sjc,
Tg(Sox10-cre)1Wdr,
Tg(Sox10-cre)507Mcln,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jjl,
Tg(Tagln-cre)1Jomm,
Tg(Tagln-cre)1Llw,
Tg(Tagln-cre/ERT2)1Feil,
Tg(Tagln-rtTA-cre)1Llw,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx18-icre)1Fech,
Tg(Tbx1-cre)1Joe,
Tg(T-cre)1Lwd,
Tg(Tek-cre)12Flv,
Tg(Tek-cre)1Arnd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre/ERT2)1Arnd,
Tg(Tek-cre)#Xya,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tie1-cre)9Ref,
Tg(Tnni3-cre/GFP)1Mknn,
Tg(Tnnt2-cre)5Blh,
Tg(Vav1-cre)1Awr,
Tg(Vav1-cre)1Cgp,
Tg(Vav1-cre)1Graf,
Tg(Vav1-cre)8Cgp,
Tg(Vil-cre)997Gum,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt1-cre)11Rth,
Tg(WT1-cre)AG11Dbdr,
Tg(Zp3-cre)3Mrt,
Thtm1(cre)Te,
Twist2tm1.1(cre)Dor,
Viptm1(cre)Zjh
(less)
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Images
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J:184579
Fig. Cck Aorta Adult
J:184579
Fig. Cck Aorta P7
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Fig. Cck Embryo2 E15.5
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Fig. Cck Embryo3 E15.5
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Fig. Cck Embryo4 E15.5
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Fig. Cck Embryo5 E15.5
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Fig. Cck Embryo6 E15.5
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Fig. Cck Heart Adult
J:184579
Fig. Cck Heart P7
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools