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Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn - Renal And Urinary System
Recombinase Activity Detail
Allele Information
gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Cristina M Backman
Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase, Transactivator)
Inducer: induced by doxycycline
Synonym: R26rtTA-TRECre
Molecular description: A targeting vector was generated that contained 5 + 3' homology arms to the first intron of the Gt(ROSA)26Sor locus, a cassette containing a splice acceptor, the improved rtTA-M2 element followed by a human TP53 intron and in opposite orientation, the tet-response element TRE-tight promoter driving a cre coding sequence (tetO-cre). The vector also contained an FRT-flanked neo selection cassette. Homologous recombination was done in R1 ES cells. Germline mice were produced and subsequently crossed to Flpe deleter mice to delete the neo cassette.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn activity also observed in:
embryo-other, nervous system, respiratory system, sensory organs, skeletal system
Tissue Information
Renal And Urinary System Other recombinase alleles with activity in Renal And Urinary System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.21
The Jackson Laboratory