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Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn
gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Cristina M Backman
Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase, Transactivator)
Inducer: induced by doxycycline
Synonym: R26rtTA-TRECre
Molecular description: A targeting vector was generated that contained 5 + 3' homology arms to the first intron of the Gt(ROSA)26Sor locus, a cassette containing a splice acceptor, the improved rtTA-M2 element followed by a human TP53 intron and in opposite orientation, the tet-response element TRE-tight promoter driving a cre coding sequence (tetO-cre). The vector also contained an FRT-flanked neo selection cassette. Homologous recombination was done in R1 ES cells. Germline mice were produced and subsequently crossed to Flpedeleter mice to delete the neo cassette.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn activity also observed in:
embryo-other, renal and urinary system, respiratory system, sensory organs, skeletal system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory