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Corttm1(cre)Zjh - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Corttm1(cre)Zjh
cortistatin; targeted mutation 1, Z Josh Huang
Driver: Cort
Type: Targeted (knock-in)
Synonym: Cst-2A-Cre
Molecular description: A targeting vector was designed to insert a T2A oligopeptide that mediates ribosomal skipping (foot-and-mouth disease virus 2A from the insect Thosea asigna virus), a cre recombinase sequence, an SV40 polyA signal, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the cortistatin locus (Cort). This construct was electroporated into C57BL6/S129 hybrid embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient tetraploid blastocysts. Chimeric mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to generate the colony and remove the neo selection cassette. The FLPe transgene has been bred out of the line.
Find mice (IMSR): Mouse Strains: 1 lines available       Cell Lines: 0 lines available
Additional Tissues: Corttm1(cre)Zjh activity also observed in:
alimentary system, renal and urinary system, reproductive system, respiratory system, skeletal system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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Fig. Cort Brain 1 P56
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Fig. Cort Brain 2 P56
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Fig. Cort Cortex P7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory