Cort<tm1(cre)Zjh> - Endocrine System Recombinase Activity Detail MGI Mouse

Cort^tm1(cre)Zjh - Endocrine System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Cort^tm1(cre)Zjh
cortistatin; targeted mutation 1, Z Josh Huang

Driver: Cort
Type: Targeted (Recombinase)

Synonym:

Cst-2A-Cre

Molecular description:

A targeting vector was designed to insert a T2A oligopeptide that mediates ribosomal skipping (foot-and-mouth disease virus 2A from the insect Thosea asigna virus), a cre recombinase sequence, an SV40 polyA signal, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the cortistatin locus (Cort). This construct was electroporated into C57BL6/S129 hybrid embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient tetraploid blastocysts. Chimeric mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background) to generate the colony and remove the neo selection cassette. The FLPe transgene has been bred out of the line.

Collection:

Neuroscience Blueprint cre

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Cort^tm1(cre)Zjh activity also observed in:

alimentary system, head, nervous system, renal & urinary system ...(more)

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

12 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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