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Tg(Slc1a3-cre/ERT2)45-72Fwp - Sensory Organs
Recombinase Activity Detail
Allele Information
Allele:
Tg(Slc1a3-cre/ERT2)45-72Fwp
transgene insertion 45-72, Frank W Pfrieger
Driver: Slc1a3
Type: Transgenic (Cre/Flp)
Inducer: induced by tamoxifen
Synonym: GLAST::CreERT2, Tg(Glast-CreERT2)45-72
Molecular description: The creERT2 expression cassette, preceded by a rabbit beta-globin DNA encompassing intron 2 (beta-globin intervening sequences [bGIVS]) and followed by the SV40 polyA signal and a PGK/Tn5-driven neomycin resistance cassette flanked by FRT sites (neo) was inserted by homologous recombination at the transcription initiation site of the Slc1a3 (Glast) gene located in BAC RP23-63O21. The linearized vector was injected into pronuclei of fertilized FVB/N eggs. Line 45-72 showed the highest level of Cre expression, which corresponded to the strong presence of Slc1a3 transcripts. Other regions of the CNS also contained CreERT2 transcripts, but at lower levels. CreERT2 mRNA was also detected in the skin and testis in agreement with elevated Slc1a3 transcript levels in these tissues.
Find mice (IMSR): Mouse Strains: 0 lines available       Cell Lines: 0 lines available
Additional Tissues: Tg(Slc1a3-cre/ERT2)45-72Fwp activity also observed in:
nervous system
Tissue Information
Sensory Organs Other recombinase alleles with activity in Sensory Organs tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory