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Tg(Gjb6-cre/ERT2)53-33Fwp - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Gjb6-cre/ERT2)53-33Fwp
transgene insertion 53-33, Frank W Pfrieger
Driver: Gjb6
Type: Transgenic (Inducible, Recombinase)
Inducer: Induced by tamoxifen
Synonym: Tg(Cx30-CreERT2)53-33
Molecular description: The creERT2 expression cassette, preceded by a rabbit beta-globin DNA encompassing intron 2 (beta-globin intervening sequences [bGIVS]) and followed by the SV40 polyA signal and a PGK/Tn5-driven neomycin resistance cassette flanked by FRT sites (neo) was inserted by homologous recombination at the transcription initiation site of the Gjb6 gene located in BAC RP24-368M7. The linearized vector was injected into pronuclei of fertilized FVB/N eggs. Line 53-33 displayed high quantities of CreERT2 transcripts in several brain regions including cortex, cerebellum, hippocampus, mesencephalon, and medulla oblongata. CreERT2 and Cx30 mRNA were also present in the skin.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory