Tg(Gjb6-cre/ERT2)53-33Fwp - Sensory Organs Recombinase Activity Detail MGI Mouse

Tg(Gjb6-cre/ERT2)53-33Fwp - Sensory Organs
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Gjb6-cre/ERT2)53-33Fwp
transgene insertion 53-33, Frank W Pfrieger

Driver: Gjb6
Type: Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Cx30-CreER^T2, Tg(Cx30-CreER^T2)53-33

Molecular description:

The creER^T2 expression cassette, preceded by a rabbit beta-globin DNA encompassing intron 2 (beta-globin intervening sequences [bGIVS]) and followed by the SV40 polyA signal and a PGK/Tn5-driven neomycin resistance cassette flanked by FRT sites (neo) was inserted by homologous recombination at the transcription initiation site of the Gjb6 gene located in BAC RP24-368M7. The linearized vector was injected into pronuclei of fertilized FVB/N eggs. Line 53-33 displayed high quantities of CreER^T2 transcripts in several brain regions including cortex, cerebellum, hippocampus, mesencephalon, and medulla oblongata. CreER^T2 and Cx30 mRNA were also present in the skin.

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Tg(Gjb6-cre/ERT2)53-33Fwp activity also observed in:
alimentary system, cardiovascular system, head, muscle, nervous system, respiratory system

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

15 reference(s)

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