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Gad2tm2(cre)Zjh - Cardiovascular System
Recombinase Activity Detail
Allele Information
glutamic acid decarboxylase 2; targeted mutation 2, Z Josh Huang
Driver: Gad2
Type: Targeted (Recombinase)
Synonym: Gad2-iCre, Gad2-ires-Cre, GAD65-Cre, GAD65-iCre, GAD65-ires-Cre
Molecular description: A targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, an SV40 polyA signal, and an frt-flanked neo cassette into the 3' untranslated region (after the translational termination site) of the Gad2 (glutamic acid decarboxylase 2) gene. This construct was electroporated into C57BL6/S129 hybrid embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient tetraploid blastocysts. Chimeric mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background (N10)) to remove the selection cassette. The FLPe transgene was subsequently bred out of the background.
Collection: Neuroscience Blueprint cre
Find mice (IMSR): Mouse Strains: 3 strains available       Cell Lines: 0 lines available
Additional Tissues: Gad2tm2(cre)Zjh activity also observed in:
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
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Fig. Gad2 Atria P56
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Fig. Gad2 E10.5 Embryo 3
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Fig. Gad2 Heart P7
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Fig. Gad2 Valve P56
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Fig. Gad2 Ventricle P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory