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Dlx5tm1(cre/ERT2)Zjh - Reproductive System
Recombinase Activity Detail
Allele Information
Allele:
Dlx5tm1(cre/ERT2)Zjh
distal-less homeobox 5; targeted mutation 1, Z Josh Huang
Driver: Dlx5
Type: Targeted (Inducible, Recombinase)
Inducer: induced by tamoxifen
Synonym: Dlx5-CreER, Dlx5-CreERT2
Molecular description: A targeting vector was designed to insert a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), an SV40 polyA signal, and an frt-flanked neo cassette into the initiation codon of the Dlx5 (distal-less homeobox 5) gene. This construct was electroporated into C57BL/6 embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts and chimeric mice were bred with white C57BL/6 mice to originate the colony. Mutant mice were bred with Actin-FLPe mice (on a C57BL/6 congenic background (N10)) to remove the neo selection cassette.
Collection: Neuroscience Blueprint cre
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Dlx5tm1(cre/ERT2)Zjh activity also observed in:
nervous system, skeletal system
Tissue Information
Reproductive System Other recombinase alleles with activity in Reproductive System tissues:
Images
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J:184579 Full image
Fig. Dlx5 Uterus P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory