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Tg(Hoxb2-cre)1Ksec - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Hoxb2-cre)1Ksec
transgene insertion 1, Katheryn S E Cheah
Driver: Hoxb2
Type: Transgenic (Recombinase)
Synonym: B2-r4-Cre
Molecular description: The 3.4 kb transgene construct contained a 1.4 kb genomic fragment containing the murine Hoxb2 rhombomere 4 enhancer (r4) inserted upstream of the beta-globin promoter to drive expression of cre cDNA with a nuclear localization signal (NLS). Five founder lines were generated. Line 5 showed mosaic expression when crossed to R26R reporter animals, while the remaining 4 recapitulated the Hoxb2-r4 expression pattern as reported previously. Lines 3 and 4 showed higher background staining while line 1 showed stronger cre activity than line 2. Line 1 was used for subsequent analyses.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(Hoxb2-cre)1Ksec activity also observed in:
branchial arches, cardiovascular system, limbs, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:149900 Fig. 1 J:149900 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory