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Tg(Gfap-cre)77.6Mvs - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Gfap-cre)77.6Mvs
transgene insertion 77.6, Michael V Sofroniew
Driver: Gfap
Type: Transgenic (Recombinase)
Synonym: mGFAP-Cre
Molecular description: The bacterial Cre recombinase gene was inserted into the first exon of an expression cassette (clone 445) that contains all the introns, promoter regulatory elements, exons, and 2.5 kb of 5' and 2 kb of 3' flanking DNA of the astroglia-specific mouse glial fibrillary acidic protein gene. GFAP is not expressed from the transgene due to deletion of part of exon 1. Cre expression was detected in a small population of cells within the subependymal zone in the adult brain. No Cre expression or activity was detected during embryonic development or in the hippocampus.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Gfap-cre)77.6Mvs activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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Fig. Gfap Brain P56
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Fig. Gfap Sp Cord (Cerv) P56
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Fig. Gfap Sp Cord (Lumb) P56
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Fig. Gfap Sp Cord (Thor) P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory