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Allele Information
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Allele:
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Inducer:
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induced by tamoxifen
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Synonym:
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Wfs1-Tg3-CreERT2
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Molecular description:
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The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405O19, containing the entire Wsf1 locus (and other genes), was modified by targeting a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Wsf1 locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre activity is directed to cortex, hippocampus, striatum, thalamus and cerebellum only following taxomifen administration.
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Find mice (IMSR):
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Mouse Strains:
1 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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Tg(Wfs1-cre/ERT2)3Aibs activity also observed in:
adipose tissue,
alimentary system,
cardiovascular system,
endocrine system,
hemolymphoid system,
integumental system,
liver and biliary system,
muscle,
nervous system,
renal and urinary system,
reproductive system,
respiratory system
(less)
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Tissue Information
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Sensory Organs
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Other recombinase alleles with activity in Sensory Organs tissues:
1700009P17Riktm1.1(icre)Heli,
Acantm1(cre/ERT2)Crm,
Acsm4tm1(cre)Hsak,
Atoh1tm1(cre)Gan,
Calb2tm1(cre)Zjh,
Ccktm1.1(cre)Zjh,
Cdkn2atm3(cre)Cjs,
Chattm1(cre/ERT)Nat,
Chattm1(cre)Lowl,
Dcttm1(cre)Bee,
Emx1tm1(cre)Krj,
Emx2tm2(cre)Sia,
En1tm2(cre)Wrst,
Fgf16tm1.1(cre)Sms,
Foxg1tm1(cre)Skm,
Gad2tm2(cre)Zjh,
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn,
Gt(ROSA)26Sortm1(cre/ERT)Nat,
Hes1tm1(cre/ERT2)Lcm,
HhatTg(TFAP2A-cre)1Will,
Hoxb1tm1(cre)Og,
Hprttm10(Ple162-EGFP/cre)Ems,
Krt12tm3(cre)Wwk,
Krt19tm1(cre)Mmt,
Mapttm3(cre/PGR)Aha,
Meox1tm1(cre)Jpa,
Mnx1tm4(cre)Tmj,
Myf5tm3(cre)Sor,
Nefltm1(cre/ERT)Nat,
Notch1tm3(cre)Rko,
Pax3tm1(cre)Joe,
Pcp2tm1(cre)Nobs,
Pvalbtm1(cre)Arbr,
Runx1tm1(cre/Esr1*)Ims,
Shhtm1(EGFP/cre)Cjt,
Six1tm1(cre,ALPP)Xli,
Sox17tm2.1(icre)Heli,
Ssttm2.1(cre)Zjh,
Tg(ACTB-cre)1Tes,
Tg(ACTB-cre)2Mrt,
Tg(Atoh1-cre)1Bfri,
Tg(Atoh1-cre/ERT)1Sbk,
Tg(Atoh1-cre/Esr1*)14Fsh,
Tg(BEST1-cre)1Jdun,
Tg(BEST1-rtTA,tetO-cre)1Yzl,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(Camk2a-cre)1Nobs,
Tg(Camk2a-cre)T29-1Stl,
Tg(CD2-cre)4Kio,
Tg(Cdh5-cre)7Mlia,
Tg(Chat-cre)GM24Gsat,
Tg(Chx10-EGFP/cre,-ALPP)2Clc,
Tg(Col2a1-cre)1Asz,
Tg(Col2a1-cre)1Bhr,
Tg(COL2A1-cre)1Wag,
Tg(Crx-cre)1Tfur,
Tg(Cryaa-cre)10Mlr,
Tg(Cryaa-cre)39Mlr,
Tg(Csrp1-cre)1Sjc,
Tg(Cyp19a1-cre)5909Gle,
Tg(Cyp19a1-cre)5912Gle,
Tg(Dct-cre)1Apdn,
Tg(Ddx4-cre)1Dcas,
Tg(Dkk3-cre)D9Tfur,
Tg(dlx6a-cre)1Mekk,
Tg(EIIa-cre)C5379Lmgd,
Tg(Eno2-cre)39Jme,
Tg(Fabp4-cre)1Rev,
Tgfb3tm1(cre)Vk,
Tg(Frzb-cre)1Tylz,
Tg(Fzd9-cre)1Chzh,
Tg(Gabra6-cre)B1Lfr,
Tg(GFAP-cre)25Mes,
Tg(GFAP-cre)8Gtm,
Tg(Ghrhr-cre)3242Lsk,
Tg(Grik4-cre)G32-4Stl,
Tg(Grm6-icre)1Rlbn,
Tg(Hand2-cre)7-1Clou,
Tg(Hoxb2-cre)1Ksec,
Tg(HRGP-cre)#Yzl,
Tg(Hspa2-cre)1Eddy,
Tg(I12b-cre)1Jlr,
Tg(Ins2-cre)25Mgn,
Tg(Jam2-cre/ERT)1Jrs,
Tg(Kdr-cre)15962Brei,
Tg(Kera-cre)KC4.3Wwk,
Tg(Kit-cre)151Eks,
Tg(KRT14-cre)1Amc,
Tg(KRT1-5-cre)5132Jlj,
Tg(KRT5-cre/ERT)SCmch,
Tg(Mbp-cre)6Gvn,
Tg(Mbp-cre)9Gvn,
Tg(mI56i-cre)6-2Clou,
Tg(Mitf-cre)7114Gsb,
Tg(MMTV-cre)4Mam,
Tg(Mpz-cre)94Imeg,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Mylpf-cre)3Kraj,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kln,
Tg(Nes-cre/ERT2)73Lfp,
Tg(Nes-phiC31*)1Imayo,
Tg(Neurog1-cre/ERT2)1Good,
Tg(Opn1mw-cre)1Asw,
Tg(Opn1sw-cre)1Asw,
Tg(Osr1-cre)4Mrt,
Tg(P0-Cre)1Gth,
Tg(Pax2-cre)1Akg,
Tg(Pax6-cre)1Knd,
Tg(Pax6-cre)1Rilm,
Tg(Pax6-cre)1Zkoz,
Tg(Pax6-cre,GFP)1Pgr,
Tg(Pax6-cre,GFP)2Pgr,
Tg(Pcp2-cre)1Amc,
Tg(Pcp2-cre)2Mpin,
Tg(Pcp2-cre)3555Jdhu,
Tg(Pdgfb-icre/ERT2)1Frut,
Tg(Pdgfra-cre)1Clc,
Tg(Pf4-cre)Q3Rsko,
Tg(Pitx3-cre/ERT2)1Ydq,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(Plp1-cre/ERT)3Pop,
Tg(POU3F4-cre)M51Cren,
Tg(Pou4f3-cre)1Devet,
Tg(Pres-cre)1Jnz,
Tg(Prm-cre)58Og,
Tg(Prnp-cre/ERT)28.4Ics,
Tg(Prph1-cre)11Dmd,
Tg(Prph1-cre)25Dmd,
Tg(Prph1-cre)35Dmd,
Tg(Prrx1-cre)1Cjt,
Tg(Rarb-cre)1Bhr,
Tg(Rbp3-cre)1Brn,
Tg(RHO-cre)16Eap,
Tg(Rho-cre)1Yzl,
Tg(Rho-cre)2Yzl,
Tg(RHO-cre)8Eap,
Tg(rx3-icre)1Mjam,
Tg(Scgb1a1-cre)1Grau,
Tg(Sim1-cre)1Lowl,
Tg(Six3-cre)69Frty,
Tg(Slc16a8-cre/ERT2,-EGFP)1Moss,
Tg(Slc1a3-cre/ERT2)45-72Fwp,
Tg(Slc6a4-cre)ET33Gsat,
Tg(Smad7-cre)1Sjc,
Tg(Sox10-cre)507Mcln,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tbx1-cre)1Joe,
Tg(TCF/Lef1-cre/ERT2)1Dje,
Tg(T-cre)1Lwd,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre/ERT2)1Soff,
Tg(Th-cre)12Mrub,
Tg(Th-cre)1Tmd,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Tlx2-cre)#Mori,
Tg(TSPY-cre)33aYfcl,
Tg(Tyr-cre)1Gfk,
Tg(Tyr-cre/ERT2)13Bos,
Tg(Tyrp1-cre)1Ipc,
Tg(Wnt1-cre)11Rth,
Thtm1(cre/Esr1)Nat,
Thtm1(cre)Te,
Twist2tm1.1(cre)Dor
(less)
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Images
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J:184579
Fig. Wsf1 Eye Adult
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools