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Tg(Wfs1-cre/ERT2)3Aibs - Nervous System
Recombinase Activity Detail
Allele Information
transgene insertion 3, Ed Lein
Driver: Wfs1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Wfs1-Tg3-CreERT2
Molecular description: The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405O19, containing the entire Wsf1 locus (and other genes), was modified by targeting a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Wsf1 locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre activity is directed to cortex, hippocampus, striatum, thalamus and cerebellum only following taxomifen administration.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Wfs1-cre/ERT2)3Aibs activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
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J:184579 Full image
Fig. Wsf1 Brain P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory