Hprt1<tm14(Ple103-EGFP/cre)Ems> - Nervous System Recombinase Activity Detail MGI Mouse

Hprt1^{tm14(Ple103-EGFP/cre)Ems} - Nervous System
Recombinase Activity Detail

Allele Information | Tissue Information | Images | Recombinase Activity | References

Allele Information

Allele:

Hprt1^{tm14(Ple103-EGFP/cre)Ems}
hypoxanthine phosphoribosyltransferase 1; targeted mutation 14, Elizabeth M Simpson

Driver: HAP1
Type: Targeted (Recombinase, Reporter)

Synonym:

HAP1-EGFP/cre, Hprt1^{tm14(mEMS675)Ems}, Hprt1^{tm14(Ple103-EGFPcre;mEMS675)Ems}, Ple103

Molecular description:

The Ple103-EGFP/cre transgene (pEMS1083) was designed with the 877 bp Ple103 minipromoter (HAP1-A; derived from a segment of the basal promoter element of the human huntingtin-associated protein 1 (HAP1) gene) upstream of a minimal F5 mutant-frt site, an EGFP/Cre fusion protein (enhanced green fluorescent protein (with mutated stop) and Cre recombinase), a nuclear localization signal, a second minimal frt site, an SV40 early polyA signal, and a human HPRT complementary sequence (containing exon1, intron1, exon2, and part of intron2). This construct was targeted as a single copy knockin to the Hprts^b-m3 mutant locus on the X chromosome.

Collection:

Pleiades Promoter Project

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Hprt1^{tm14(Ple103-EGFP/cre)Ems} activity also observed in:
head

Tissue Information

Nervous System

Other recombinase alleles with activity in Nervous System tissues:

7630403G23Rik^{Tg(Th-cre)1Tmd}, Abcg2^{tm1.1(cre/Esr1*)Jvbe}, Acsm4^tm1(cre)Hsak, Adcyap1r1^{tm1.1(cre/GFP)Rpa} ...(more)

Images

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J:164356 Fig. 4

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

3 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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