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Tg(Gh1-cre)1Sac - Endocrine System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Gh1-cre)1Sac
transgene insertion 1, Sally A Camper
Driver: Gh1
Type: Transgenic (Cre/Flp)
Synonym: Tg(Gh-cre)SAC1
Molecular description: The human growth hormone locus control region (-16.2 to -14.6 kb relative to the GH1 promoter) was fused to 1.77 kb of rat Gh1 promoter to drive expression of a cre recombinase cassette in the pituitary gland. About 30-50 copies of the transgene construct inserted into the genome after injection into zygotes. When crossed with cre-reporter strains, cre expression was observed in the pituitary somatotropes, with limited expression in lactotropes, and no detectable expression in other pituitary cell types. Cre expression was also detected in the skin of embryonic forelimbs and trunk, and in adult testis, ovary, and kidney.
Find mice (IMSR): Mouse Strains: 1 lines available       Cell Lines: 0 lines available
Additional Tissues: Tg(Gh1-cre)1Sac activity also observed in:
limbs, renal and urinary system, reproductive system, respiratory system
Tissue Information
Endocrine System Other recombinase alleles with activity in Endocrine System tissues:
Images
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J:144723 Fig. 1 J:144723 Fig. 2 J:144723 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory