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Mcm2tm1(cre/ERT2)Scpr - Hemolymphoid System
Recombinase Activity Detail
Allele Information
Allele:
Mcm2tm1(cre/ERT2)Scpr
minichromosome maintenance deficient 2 mitotin (S. cerevisiae); targeted mutation 1, Steven C Pruitt
Driver: Mcm2
Type: Targeted (Recombinase)
Synonym: Mcm2IRES-CreERT2, Mcm2tm1(cre)Scpr
Molecular description: An IRES element, a cre/ESRI fusion gene. and a PGK-neo selection cassette were inserted into exon 16 3' to the stop codon. A cryptic polyA site 3' of the stop codon was deleted in order to permit cre expression. Cre expression was confirmed by EGFP expression after tamoxifen treatment of mice also carrying the Tg(CAG-Bgeo/GFP)21Lbe transgene. MCM2 expression was reduced to 62% of normal in heterozygotes and 35% in homozygotes.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Mcm2tm1(cre/ERT2)Scpr activity also observed in:
alimentary system, cardiovascular system, integumental system, nervous system
Tissue Information
Hemolymphoid System Other recombinase alleles with activity in Hemolymphoid System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory