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Agrptm1(cre)Lowl - Renal & Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Agrptm1(cre)Lowl
agouti related neuropeptide; targeted mutation 1, Bradford B Lowell 		Driver: Agrp
Type: Targeted (Recombinase)
Synonym: Agrp-Cre, Agrp-Ires-cre
Molecular description: An IRES-cre-frt-kan/neo-frt cassette was inserted in frame in exon 5 after the stop codon via homologous recombination. The kan/neo cassette was subsequently removed via in vivo Flp mediated recombination. Crosses to reporter mice detected Cre activity in AGRP+ neurons. The mutation resulted in a duplication of chromosome 8 genomic sequence at least 53 kb in size that inserted into intron 1 of the nearby Ripor1 (Fam65a) locus. The duplicated sequence includes the entire Hsd11b2 locus, the entire Atp6v0d1 locus and at least 11.7 kb of the Agrp locus. The insertion appears to be in the ~9 kb intron upstream of the translation start site-containing exon 2,however, the effect on Ripor1 expression was not specifically analyzed.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Agrptm1(cre)Lowl activity also observed in:
Tissue Information
Renal & Urinary System Other recombinase alleles with activity in Renal & Urinary System tissues:
Images
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J:193672 Full Image
Fig. Agrp Kidney P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 175 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory