Hcn4<tm1(cre/ERT2)Anlu> - Nervous System Recombinase Activity Detail MGI Mouse

Hcn4^{tm1(cre/ERT2)Anlu} - Nervous System
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Hcn4^{tm1(cre/ERT2)Anlu}
hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1, Andreas Ludwig

Driver: Hcn4
Type: Targeted (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

HCN4-KiT, HCN4KiT-Cre, Hcn4^{tm1(cre/ESR1)Anlu}

Molecular description:

A cre/ERT2 fusion gene and a neo cassette were inserted into exon 1 downstream of the translation initiation codon. Expression is tamoxifen inducible and localized to the superior vena cava in the proximity of the right atrial appendage and the aorta, specifically in the sinoatrial and atrioventricular nodes.

Find mice (IMSR):

Mouse Strains: 0 strains available Cell Lines: 0 lines available

Additional Tissues:

Hcn4^{tm1(cre/ERT2)Anlu} activity also observed in:
cardiovascular system, muscle

Recombinase Activity

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Assays Genotypic Background Result Notes

References

All for this allele:

9 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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