The Myh6 promoter was used to drive cardiac myocyte-specific expression of an inducible cre fused to the mutated ligand binding domain of human PGR (amino acids 641-891). Three founder lines, 6306, 6297, and 6299, were generated with line 6306 showing the lowest level of cre protein by Western blot and lowest prevalence of ligand-dependent recombination, with 6299 showing highest level of recombination. Copy number was found to be highest in 6299 (about 10) with 6306 having the lowest (1).
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Other recombinase alleles with activity in Cardiovascular System tissues: