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Gt(ROSA)26Sortm2(icre/ERT2)Jphe - Muscle
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm2(icre/ERT2)Jphe
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jean-Paul Herman
Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase)
Inducer: induced by tamoxifen
Synonym: Cre2ERT2, ERT2-iCre-ERT2, Gt(ROSA)26Sortm2(cre/ESR1)Jphe
Molecular description: A humanized cre gene flanked by 2 tamoxifen-binding domains (ERT2-icre-ERT2) and followed by an frt-flanked hygro cassette was knocked into the locus. Inducible cre expression is present in all cells following treatment with tamoxifen with only the brainexhibiting decresed expression levels.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm2(icre/ERT2)Jphe activity also observed in:
Tissue Information
Muscle Other recombinase alleles with activity in Muscle tissues:
Images
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J:135150 Fig. 2 J:135150 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory