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Gt(ROSA)26Sortm2(icre/ERT2)Jphe - Muscle
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm2(icre/ERT2)Jphe
gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Jean-Paul Herman
Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase)
Inducer: induced by tamoxifen
Synonym: Cre2ERT2, ERT2-iCre-ERT2, Gt(ROSA)26Sortm2(cre/ESR1)Jphe
Molecular description: A humanized cre gene flanked by 2 tamoxifen-binding domains (ERT2-icre-ERT2) and followed by an frt-flanked hygro cassette was knocked into the locus. Inducible cre expression is present in all cells following treatment with tamoxifen with only the brain exhibiting decresed expression levels.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm2(icre/ERT2)Jphe activity also observed in:
Tissue Information
Muscle Other recombinase alleles with activity in Muscle tissues:
Images
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J:135150 Fig. 2 J:135150 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory