About   Help   FAQ
Gt(ROSA)26Sortm1.1(CAG-cre)Jphe - Reproductive System
Recombinase Activity Detail
Allele Information
gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Jean-Paul Herman
Driver: CAG
Type: Targeted (Inducible, Recombinase)
Inducer: rapamycin
Synonym: DiCre, Gt(ROSA)26Sortm1.1(cre)Jphe, Rosa26-DiCre
Molecular description: The expression of a dimerizable cre was achieved by insertion of the cre60.F2 N-terminal cre moiety which is fused to FRB (ligand binding domain of FRAP/MTOR,an FKBP12-rapamycin associated protein) under the control of the endogenous promoter and a Caggs-cre59.F2 cassette, containing the C-teminal moiety of cre fused to FKBP12 (FK506-binding protein) under control of the CAG promoter, into the ROSA locus. A hygro cassette was also inserted into the locus for selection purposes. The split cre is inactive until dimerization is induced by administration of rapamycin. The hygro cassette was removed by crossing F1 Gt(ROSA)26Sortm1(cre)Jphe mice with FLPe mice.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1.1(CAG-cre)Jphe activity also observed in:
Tissue Information
Reproductive System Other recombinase alleles with activity in Reproductive System tissues:
Drag images to compare to others or to data in the table below. Drag corners to resize images for more detail. Reset Images
J:130959 Fig. 4
Recombinase Activity
Click heading to re-sort table.
Assays Genotypic Background Result Notes  
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.03
The Jackson Laboratory