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Gt(ROSA)26Sortm1.1(cre)Jphe - Renal And Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Gt(ROSA)26Sortm1.1(cre)Jphe
gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Jean-Paul Herman
Driver: Gt(ROSA)26Sor
Type: Targeted (Inducible, Recombinase)
Inducer: induced by rapamycin
Synonym: DiCre, Rosa26-DiCre
Molecular description: The expression of a dimerizable cre was achieved by insertion of the cre60.F2 N-terminal cre moiety which is fused to FRB (ligand binding domain of FRAP,an FKBP12-rapamycin associated protein) under the control of the endogenous promoter and a Caggs-cre59.F2 cassette, containing the C-teminal moiety of cre fused to FKBP12 (FK506-binding protein) under control of the CAG promoter, into the ROSA locus. A hygro cassette was also inserted into the locus for selection purposes. The split cre is inactive until dimerization is induced by administration of rapamycin. The hygro cassette was removed by crossing F1 Gt(ROSA)26Sortm1(cre)Jphe mice with FLPe mice.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Gt(ROSA)26Sortm1.1(cre)Jphe activity also observed in:
Tissue Information
Renal And Urinary System Other recombinase alleles with activity in Renal And Urinary System tissues:
Images
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J:130959 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory