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Tg(Nkx2-1-cre)2Sand - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Nkx2-1-cre)2Sand
transgene insertion 2, Stewart Anderson
Driver: Nkx2-1
Type: Transgenic (Recombinase)
Synonym: Nkx2-1BACCre, Nkx2.1-cre, NKX2.1Cre, Tg(Nkx2-1-cre)1Qixu, Tg(Nkx2-1-cre)2Qixu, Ttf-1Cre
Molecular description: A mouse BAC clone containing the Nkx2-1 gene was engineered to express cre recombinase. Fifteen base pairs at the 5'end of exon 2 of the Nkx2-1 gene were replaced with a cre-poly(A) construct. The mutated BAC clone was then used to generate transgenic mice. This construct is expressed in brain, thyroid, pituitary, and lung, with telecephalic expression first detectable at E10.5.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Nkx2-1-cre)2Sand activity also observed in:
alimentary system, mesenchyme, respiratory system
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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Fig. Nkx2-1 Brain1 P56
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Fig. Nkx2-1 E10.5 Embryo 1
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Fig. Nkx2-1 E10.5 Embryo 2
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Fig. Nkx2-1 E10.5 Embryo 3
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Fig. Nkx2-1 E15.5 Embryo 1
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Fig. Nkx2-1 E15.5 Embryo 2
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Fig. Nkx2-1 E15.5 Embryo 3
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Fig. Nkx2-1 P7 Brain
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Fig. Nkx2 Brain2 P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory