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Tg(Ascl1-cre/Esr1*)1Jejo - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Ascl1-cre/Esr1*)1Jejo
transgene insertion 1, Jane Johnson
Driver: Ascl1
Type: Transgenic (Inducible, Recombinase)
Inducer: induced by tamoxifen
Synonym: Ascl1-CreERTM, line B2C-6, Mash1BAC-CreER, Tg(Ascl1-cre/ESR1)1Jejo
Molecular description: The transgene contains a BAC in which the Ascl1 open reading frame is replaced with a cre-estrogen response element fusion. Expression of cre, detected following a cross to a reporter strain, is restricted to the midbrain at E10.5, the developing sympathetic neurons at E10.5 and E11.5, the enteric nervous system, diencephalon and hindbrain at E11.5, and the dorsal neural tube at E12.5 reflecting the endogenous expression pattern of the gene. Two lines were established (B2C-6 and B2C-8). B2C-6 was analyzed in more detail and is represented by line 1 here.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:117032 Fig. 3 J:117032 Fig. 4 J:117032 Fig. 5 J:117032 Fig. 6
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory