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Tg(NPHS2-rtTA,tetO-cre)1Holt - Renal And Urinary System
Recombinase Activity Detail
Allele Information
Allele:
Tg(NPHS2-rtTA,tetO-cre)1Holt
transgene insertion 1, Harry Holthofer
Driver: NPHS2
Type: Transgenic (Inducible, Recombinase)
Inducer: induced by doxycycline
Synonym: JRC-CRE
Molecular description: A rtTA gene modified to respond to less doxycycline was placed under the control of the human NPHS2 gene, which is only expressed in the podocytes of the kidney. In the same vector, a modified CMV promoter with a rtTA responsive element was used to drive expression of cre recombinase. Sixteen founder mice were created, and one was selected for further breeding based on doxycycline-induced expression of cre recombinase that was only detected in kidney podocyte cells.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Renal And Urinary System Other recombinase alleles with activity in Renal And Urinary System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory