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Lgr5tm1(cre/ERT2)Cle - Alimentary System
Recombinase Activity Detail
Allele Information
leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Hans Clevers
Driver: Lgr5
Type: Targeted (Inducible, Recombinase, Reporter)
Inducer: tamoxifen
Synonym: Lgr5-cre, Lgr5-creERT, Lgr5-EGFP, Lgr5 EGFP-IRES-creERT2, Lgr5-EGFP-IRES-creERT2, Lgr5tm1(cre/ESR1)Cle
Molecular description: An EGFP-IRES-creERT2 cassette was inserted into exon 1 of the gene along with a loxP-flanked neomycin cassette. The neomycin gene was then excised in vivo by crossing with cre-deleter strain. GFP expression is driven by the endogenous promoter. Cre expression is induced in Lgr5 expressing cells by tamoxifen treatment.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Lgr5tm1(cre/ERT2)Cle activity also observed in:
integumental system, reproductive system
Tissue Information
Alimentary System Other recombinase alleles with activity in Alimentary System tissues:
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J:184579 Full image
Fig. Lgr5 Sm Intest 1 P56
J:184579 Full image
Fig. Lgr5 Sm Intest 2 P56
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 150 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory