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Runx1tm1(cre/Esr1*)Ims - Nervous System
Recombinase Activity Detail
Allele Information
runt related transcription factor 1; targeted mutation 1, Igor M Samokhvalov
Driver: Runx1
Type: Targeted (Hypomorph, Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Runx1Cre, Runx1CreER, Runx1MER-Cre-MER, Runx1tm1(cre)Ims
Molecular description: A targeting vector was designed to insert a tamoxifen-inducible cre recombinase flanked by two mutated estrogen receptors and a floxed neo into the Runx1 gene downstream of the proximal (P2) promoter. The neo was subsequently removed via exogenous cre expression. A subsequent reference states that the allele was determined to be hypomorphic, with homozygotes developing to term but dying in the first postnatal day.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Runx1tm1(cre/Esr1*)Ims activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
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J:121435 Fig. 1
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory