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Allele Information
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Allele:
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Runx1tm1(cre/Esr1*)Ims
runt related transcription factor 1;
targeted mutation 1, Igor M Samokhvalov
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Driver: Runx1
Type: Targeted (knock-in)
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Inducer:
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induced by tamoxifen
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Synonym:
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Runx1MER-Cre-MER, Runx1tm1(cre)Ims, Runx1Cre
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Molecular description:
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A targeting vector was designed to insert a tamoxifen-inducible cre recombinase flanked by two mutated estrogen receptors and a floxed neo into the Runx1 gene downstream of the proximal (P2) promoter. The neo was subsequently removed via exogenous cre expression. A subsequent reference states that the allele was determined to be hypomorphic, with homozygotes developing to term but dying in the first postnatal day.
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Find mice (IMSR):
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Mouse Strains:
0 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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Runx1tm1(cre/Esr1*)Ims activity also observed in:
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Tissue Information
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Extraembryonic Component
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Other recombinase alleles with activity in Extraembryonic Component tissues:
Foxa2tm2.1(cre/Esr1*)Moon,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Hnf4atm1(cre)Sdv,
Kdrtm1(cre)Sato,
Krt19tm1(cre)Mmt,
Mapttm1(cre)Nagy,
Meox2tm1(cre)Sor,
Nkx2-5tm2(cre)Rph,
Notch1tm3(cre)Rko,
Runx1tm2.1(cre/Esr1*)Ims,
Sox17tm1(icre)Heli,
Sox17tm2.1(icre)Heli,
Tg(Acvrl1-cre)L1Spo,
Tg(Cdh5-cre)1Spe,
Tg(Cdh5-cre)7Mlia,
Tg(Cdh5-cre/ERT2)CIVE23Mlia,
Tg(Cdx1-cre)23Kem,
Tg(Cyp19a1-cre)5912Gle,
Tg(EIIa-cre)C5379Lmgd,
Tg(Foxa3-cre)1Khk,
Tg(Gata1-cre)1Sho,
Tg(Gcm1-cre)1Chrn,
Tg(HBB-cre)12Kpe,
Tg(HBB-cre)27038Kpe,
Tg(HBB-cre)27053Kpe,
Tg(Hoxb6-cre)A5Mku,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb6-cre)Mku,
Tg(Itga2b-cre)NE1/21Emam,
Tg(Kdr-cre)15962Brei,
Tg(Leftb-cre)1Hmd,
Tg(Nes-cre)1Atp,
Tg(Prdm1-cre)1Masu,
Tg(Sox2-cre)1Amc,
Tg(Tagln-cre)1Her,
Tg(Tagln-cre)1Jomm,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tal1-cre/ERT)42-056Jrg,
Tg(T-cre)1Lwd,
Tg(Tek-cre)1Ywa,
Tg(Tek-cre)2352Rwng,
Tg(Thy1-cre)1Vln,
Tg(Tie1-cre)9Ref,
Tg(Tlx2-cre)#Mori,
Tg(Tpbpa-cre,-EGFP)5Jcc,
Tg(Ttr-cre)1Hadj,
Tg(Vav1-cre)8Cgp,
Tg(Vil-cre)20Syr,
Twist2tm1.1(cre)Dor
(less)
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools
