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Tg(UBC-cre/ERT2)1Ejb - Nervous System
Recombinase Activity Detail
Allele Information
transgene insertion 1, Eric J Brown
Driver: UBC
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Cre-ER, Cre-ERT2, CreT2, Tg(UBC-cre)1Ejb, Tg(UBC-cre/ESR1)1Ejb, Ubc-cre, Ubc-creER, UBC-Cre-ER-LBD-tg, Ubc-cre/ERT2, UBC-CreERt2
Molecular description: This Cre-ERT2 transgenic mouse line was generated via lentitransgenesis; a self-inactivating lentiviral vector was designed with the human ubiquitin C (UBC) promoter sequence upstream of a Cre-ERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Cre-ERT2-expressing lentivirus were microinjected into the perivitelline space of one-cell zygotes (129SvEv;C57BL/6 mixed genetic background). Mice display tamoxifen-inducible Cre activity in all tissue types.
Find mice (IMSR): Mouse Strains: 3 strains available       Cell Lines: 0 lines available
Additional Tissues: Tg(UBC-cre/ERT2)1Ejb activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
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J:119731 Fig. 1 J:206504 Full image
Fig. UBC Adult Brain
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Fig. UBC Adult Brain 2
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Fig. UBC Adult Brain 3
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Fig. UBC Adult PNS
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Fig. UBC Adult Spinal Column
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Fig. UBC Adult Spinal Cord
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 107 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory