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Slc6a3tm1(cre)Xz - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Slc6a3tm1(cre)Xz
solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Xiaoxi Zhuang
Driver: Slc6a3
Type: Targeted (Recombinase)
Synonym: DAT-cre, Slc6a3Cre
Molecular description: A targeting vector was constructed by inserting a cassette with the cre recombinase coding sequence, a nuclear translocation signal, and a PGK-neo gene flanked by FRT sites, into the 5'-UTR of the Slc6a3 gene. After homologous recombination in ES cells, mice with cre recombinase expressed from the Slc6a3 gene were produced. Knockin mice were crossed with transgenic Flp deleter mice to remove the neo marker. A line was established where the neo was removed and the Flp transgene was absent. Cre recombinase expression is detected in the ventral tegmental area (VAT) and substantia nigra zona compacta (SNc).
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
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J:151962 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory