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Chattm1(cre)Lowl - Reproductive System
Recombinase Activity Detail
Allele Information
Allele:
Chattm1(cre)Lowl
choline acetyltransferase; targeted mutation 1, Bradford B Lowell
Driver: Chat
Type: Targeted (Recombinase)
Synonym: ChAT-IRES-Cre
Molecular description: An optimized internal ribosome entry sequence (IRES) fused to cre recombinase followed by a neomycin resistance cassette flanked FRT sites was inserted after the ChAT stop codon in BAC (bMQ185k21) using homologous recombination in bacteria. A genomic ChAT fragment with 4kb homology arms on either side of the IRES-Cre insertion site was lifted out from the BAC using reverse recombineering techniques and transformed into ES cells. The neo cassette was excised with Flp recombinase. Cre recombinase activity is reported in all cholinergic neurons. This allele generated from Chattm2(cre)Lowl.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Chattm1(cre)Lowl activity also observed in:
alimentary system, integumental system, nervous system, renal and urinary system, sensory organs
Tissue Information
Reproductive System Other recombinase alleles with activity in Reproductive System tissues:
Images
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J:184579 Full image
Fig. Chat Uterus P56
J:184579 Full image
Fig. Chat Uterus P7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory