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Allele Information
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Allele:
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Chattm1(cre)Lowl
choline acetyltransferase;
targeted mutation 1, Bradford B Lowell
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Driver: Chat
Type: Targeted (knock-in)
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Synonym:
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ChAT-IRES-Cre
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Molecular description:
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An optimized internal ribosome entry sequence (IRES) fused to cre recombinase followed by a neomycin resistance cassette flanked FRT sites was inserted after the ChAT stop codon in BAC (bMQ185k21) using homologous recombination in bacteria. A genomic ChAT fragment with 4kb homology arms on either side of the IRES-Cre insertion site was lifted out from the BAC using reverse recombineering techniques and transformed into ES cells. The neo cassette was excised with Flp recombinase. Cre recombinase activity is reported in all cholinergic neurons. This allele generated from Chattm2(cre)Lowl.
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Find mice (IMSR):
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Mouse Strains:
1 lines available
Cell Lines:
0 lines available
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Additional Tissues:
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Chattm1(cre)Lowl activity also observed in:
alimentary system,
integumental system,
renal and urinary system,
reproductive system,
sensory organs
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Tissue Information
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Nervous System
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Other recombinase alleles with activity in Nervous System tissues:
1700009P17Riktm1.1(icre)Heli,
Acsm4tm1(cre)Hsak,
Agrptm1(cre)Lowl,
Airetm3(cre)Mmat,
Alpltm1(cre)Nagy,
Atoh1tm1(cre)Gan,
Bhlhe22tm2(cre)Gan,
Calb2tm1(cre)Zjh,
Calb2tm2.1(cre/ERT2)Zjh,
Ccktm1.1(cre)Zjh,
Ccktm2.1(cre/ERT2)Zjh,
Chattm1(cre/ERT)Nat,
Cnptm1(cre)Kan,
Corttm1(cre)Zjh,
Crhtm1(cre)Zjh,
Cux2tm1.1(cre)Mull,
Cux2tm2.1(cre)Mull,
Cux2tm3.1(cre/ERT2)Mull,
Dbx1tm1.1(cre)Mull,
Dcttm1(cre)Bee,
Dlx1tm1(cre/ERT2)Zjh,
Dlx5tm1(cre/ERT2)Zjh,
Dmbx1tm3(cre)Aoh,
Drd1atm1(cre)Rpa,
Egr2tm2(cre)Pch,
Emx1tm1(cre)Ito,
Emx1tm1(cre)Krj,
Emx2tm2(cre)Sia,
En1tm2(cre)Wrst,
En1tm7(cre/ESR1)Alj,
En2tm4(cre/ERT2)Alj,
Et(cre/ERT2)1382Rdav,
Et(cre/ERT2)1642Rdav,
Et(cre/ERT2)1957Rdav,
Et(cre/ERT2)2007Rdav,
Et(cre/ERT2)21Rdav,
Et(cre/ERT2)278Rdav,
Et(cre/ERT2)296Rdav,
Et(cre/ERT2)398Rdav,
Et(cre/ERT2)6691Rdav,
Et(cre/ERT2)6959Rdav,
Et(cre/ERT2)7089Rdav,
Et(cre/ERT2)7149Rdav,
Et(cre/ERT2)8120Rdav,
Et(cre/ERT2)8131Rdav,
Et(cre/ERT2)837Rdav,
Et(cre/ERT2)9699Rdav,
Et(EGFP/cre)16055Rdav,
Et(EGFP/cre)16102Rdav,
Et(EGFP/cre)16218Rdav,
Et(EGFP/cre)16250Rdav,
Et(EGFP/cre)16255Rdav,
Et(EGFP/cre)16261Rdav,
Et(icre)1402Rdav,
Et(icre)1470Rdav,
Et(icre)1555Rdav,
Et(icre)754Rdav,
Et(icre/ERT2)10596Rdav,
Et(icre/ERT2)10727Rdav,
Etv1tm1.1(cre/ERT2)Zjh,
Fgf16tm1.1(cre)Sms,
Foxa2tm2.1(cre/Esr1*)Moon,
Foxg1tm1(cre)Skm,
Gabra6tm2(cre)Wwis,
Gad2tm1(cre/ERT2)Zjh,
Gad2tm2(cre)Zjh,
Gli1tm3(cre/ERT2)Alj,
Grhl3tm1(cre)Cgh,
Grid2tm1(cre/PGR)Ksak,
Grik4tm1(cre)Ksak,
Gt(ROSA)26Sortm1.1(rtTA,tetO-cre)Bkmn,
Gt(ROSA)26Sortm1(cre/ERT2)Tyj,
Gt(ROSA)26Sortm1(cre/ERT)Nat,
Gt(ROSA)26Sortm1(FLP1)Dym,
Gt(ROSA)26Sortm2(cre/ERT2)Brn,
Gt(ROSA)26Sortm2(icre/ERT2)Jphe,
Hdctm1.1(cre)Wwis,
Hoxb1tm1(cre)Og,
Hprttm10(Ple162-EGFP/cre)Ems,
Hprttm14(Ple103-EGFP/cre)Ems,
Hprttm16(Ple167-EGFP/cre)Ems,
Hprttm1(cre)Mnn,
Hprttm9(Ple178-EGFP/cre)Ems,
Hsd11b2tm1(cre)Anft,
Isl1tm1(cre/Esr1*)Krc,
Isl1tm1(cre)Tmj,
Kdrtm1(cre)Sato,
Krt19tm1(cre)Mmt,
Lhx6tm1(cre/ERT2)Zjh,
Lyz2tm1(cre)Ifo,
Mapttm1(cre)Nagy,
Mapttm2(cre)Aha,
Mapttm3(cre/PGR)Aha,
Mcm2tm1(cre/ERT2)Scpr,
Mnx1tm4(cre)Tmj,
Mogtm1(cre)Gkl,
Myf5tm1(cre)Mrc,
Myf5tm3(cre)Sor,
Nefltm1(cre/ERT)Nat,
Neurod6tm1(cre)Kan,
Nkx2-1tm1.1(cre/ERT2)Zjh,
Nos1tm1.1(cre/ERT2)Zjh,
Notch1tm3(cre)Rko,
Omptm4(cre)Mom,
Osr2tm2(cre)Jian,
Otoftm1.1(cre)Mull,
Pax3tm1(cre)Joe,
Pcp2tm1(cre)Nobs,
Pvalbtm1(cre)Arbr,
Pvalbtm1(cre/ERT2)Zjh,
Runx1tm1(cre/Esr1*)Ims,
Scn10atm2(cre)Jnw,
Scn10atm3(cre/ERT2)Jnw,
Shhtm1(EGFP/cre)Cjt,
Six1tm1(cre,ALPP)Xli,
Slc1a3tm1(cre/ERT2)Mgoe,
Slc6a3tm1.1(cre)Bkmn,
Slc6a3tm1(cre)Xz,
Slc6a4tm1(cre)Xz,
Sox17tm2.1(icre)Heli,
Ssttm1(cre/ERT2)Zjh,
Ssttm2.1(cre)Zjh,
Taglntm2(cre)Yec,
Tfap2etm1(cre)Will,
Tg(ACTA1-cre)79Jme,
Tg(ACTA2-cre)1Miwa,
Tg(Acta2-cre/ERT2)12Pcn,
Tg(Acta2-cre/ERT2)51Pcn,
Tg(ACTFLPe)9205Dym,
Tg(Acvrl1-cre)B1Spo,
Tg(Acvrl1-cre)L1Spo,
Tg(Adora2a-cre)2MDkde,
Tg(Agrp-cre)1Gsb,
Tg(Agrp-cre)2Gsb,
Tg(Aire-cre)410-5Mmat,
Tg(Alb1-cre)1Dlr,
Tg(Ascl1-cre)1Fgu,
Tg(Ascl1-cre/Esr1*)1Jejo,
Tg(Ascl1-EGFP,-cre)1Jejo,
Tg(Atoh1-cre)1Bfri,
Tg(Atoh1-cre/ERT)1Sbk,
Tg(Atoh1-cre/Esr1*)14Fsh,
Tg(ATP6V1B1-cre)45Rnel,
Tg(Avil-cre)1Phep,
Tg(CA2-cre)1Subw,
Tg(CA2-cre/Esr1*)1Subw,
Tg(CAG-cre)13Miya,
Tg(CAG-cre/Esr1*)1Lbe,
Tg(CAG-cre/Esr1*)5Amc,
Tg(Camk2a-cre)159Kln,
Tg(Camk2a-cre)1Gsc,
Tg(Camk2a-cre)1Lfr,
Tg(Camk2a-cre)1Nobs,
Tg(Camk2a-cre)1Szi,
Tg(Camk2a-cre)2834Lusc,
Tg(Camk2a-cre)2Gsc,
Tg(Camk2a-cre)2Szi,
Tg(Camk2a-cre)3487Cnl,
Tg(Camk2a-cre/ERT2)1Aibs,
Tg(Camk2a-cre/ERT2)1Casa,
Tg(Camk2a-cre/ERT2)2Gsc,
Tg(Camk2a-cre)M34Stl,
Tg(Camk2a-cre/PGR)1Gsc,
Tg(Camk2a-cre)T17Stl,
Tg(Camk2a-cre)T29-1Stl,
Tg(Camk2a-cre)T29-2Stl,
Tg(Camk2a-cre)T50Stl,
Tg(CD2-cre)4Kio,
Tg(Cdh5-cre)7Mlia,
Tg(Cga-cre)3Sac,
Tg(Chat-cre)GM24Gsat,
Tg(Chat-cre)GM53Gsat,
Tg(Chat-cre)GM60Gsat,
Tg(Chst4-cre)1Hkwa,
Tg(Cmtm5-cre)GM160Gsat,
Tg(CMV-cre)1And,
Tg(CMV-cre)1Cgn,
Tg(Col1a2-cre)23Angl,
Tg(Col2a1-cre)10Amc,
Tg(Col2a1-cre)15Amc,
Tg(Col2a1-cre)1Asz,
Tg(COL2A1-cre)1Wag,
Tg(Col2a1-cre)3Amc,
Tg(Crh-cre)1Kres,
Tg(Crx-cre)1Tfur,
Tg(Cryaa-cre)10Mlr,
Tg(Cspg4-cre)1Akik,
Tg(Cspg4-cre/Esr1*)BAkik,
Tg(Csrp1-cre)1Sjc,
Tg(Cyp11a1-cre)16Mchu,
Tg(Cyp17a1-cre)ACmk,
Tg(Cyp19a1-cre)5909Gle,
Tg(Cyp19a1-cre)5912Gle,
Tg(Dach1-cre)1Krs,
Tg(DBH-cre)1Cse,
Tg(DBH-cre)6-8Koba,
Tg(DBH-cre)9-9Koba,
Tg(Dbh-cre/ERT2)198.1Hroh,
Tg(Dbh-icre)1Gsc,
Tg(Dbx1-cre)1Wdr,
Tg(Dct-cre)1Apdn,
Tg(DCX-cre)35Mull,
Tg(Dcx-cre)38Mull,
Tg(DCX-cre/ERT2)1Mull,
Tg(Dhh-cre)1Mejr,
Tg(dlx6a-cre)1Mekk,
Tg(DMRT1-cre)1Svs,
Tg(Drd1a-cre)120Mxu,
Tg(Drd1a-cre)1Gsc,
Tg(Drd1a-cre)AGsc,
Tg(Drd2-cre)ER43Gsat,
Tg(Drd2-cre)ER44Gsat,
Tg(Ebf2-EGFP/icre)1Ggc,
Tg(EIIa-cre)C5379Lmgd,
Tg(Emx1-cre)1Ito,
Tg(Emx1-cre)1Wdr,
Tg(Emx1-cre)2Ito,
Tg(Emx1-cre)3Ito,
Tg(Emx1-cre)5Yql,
Tg(Emx1-cre/ERT2)1Wdr,
Tg(En2-cre)11Alj,
Tg(En2-cre)22Alj,
Tg(En2-cre)3Alj,
Tg(En2-cre)4Alj,
Tg(En2-cre)6Alj,
Tg(En2-cre/ERT)1Alj,
Tg(Eno2-cre)1Lfp,
Tg(Eno2-cre)26Fsky,
Tg(Eno2-cre)2Lfp,
Tg(Eno2-EGFP/cre)1Ngc,
Tg(Eno2-EGFP/cre)25kb1Ngc,
Tg(Eno2-EGFP/cre)25kb2Ngc,
Tg(Etv1-cre)GM225Gsat,
Tg(Fabp4-cre)1Rev,
Tg(Fabp7-cre)1Htz,
Tg(Fabp7-cre)2Gtm,
Tgfb3tm1(cre)Vk,
Tg(Fev-cre)1Esd,
Tg(Fev-cre)2Esd,
Tg(Fev-FLPe)1Dym,
Tg(Foxa2*-cre)#Mku,
Tg(FOXJ1-cre)F26Htzm,
Tg(Frzb-cre)1Tylz,
Tg(Fzd10-cre/Esr1*)1Chzh,
Tg(Fzd9-cre)1Chzh,
Tg(Gabra6-cre)B1Lfr,
Tg(Gabra6-cre)CWwis,
Tg(Gata1-cre)1Sho,
Tg(GFAP-cre)1Gtm,
Tg(GFAP-cre)1Kdmc,
Tg(GFAP-cre)25Mes,
Tg(Gfap-cre)2Brn,
Tg(Gfap-cre)73.12Mvs,
Tg(Gfap-cre)77.6Mvs,
Tg(GFAP-cre)8Gtm,
Tg(GFAP-cre/ERT2)13Kdmc,
Tg(GFAP-cre/Esr1*)10Kdmc,
Tg(GFAP-cre/Esr1*,-lacZ)ASbk,
Tg(GFAP-cre/Esr1*,-lacZ)BSbk,
Tg(Gh1-cre)1Sac,
Tg(Ghrhr-cre)3242Lsk,
Tg(Gjb6-cre/ERT2)53-33Fwp,
Tg(Gnrh1-cre)1Dlc,
Tg(Gnrh1-cre)1Gsc,
Tg(Gnrh1-cre)1Rsp,
Tg(Gnrh1-cre)35Awo,
Tg(Gnrh1-tetO-cre,CMV-tetR)1Awo,
Tg(Grik4-cre)1Phs,
Tg(Grik4-cre)G32-4Stl,
Tg(Grik4-cre)G35-3Stl,
Tg(Grin2c-cre/PGR)25Mim,
Tg(Gsx2-cre)1Wdr,
Tg(Hand2-cre)7-1Clou,
Tg(Hbb/Hoxa2-cre)1Fmr,
Tg(HCRT-cre)1Stak,
Tg(Hoxa1-cre)1Tlu,
Tg(Hoxa2-cre)1Dym,
Tg(Hoxb2-cre)1Ksec,
Tg(Hoxb3-cre)1Pkht,
Tg(Hoxb6-cre)C33Mku,
Tg(Hoxb7-cre)13Amc,
Tg(Hoxb7-cre)1Jpa,
Tg(Hoxb7-cre)5526Cmb,
Tg(Hoxb8-cre)1403Uze,
Tg(Hspa2-cre)1Eddy,
Tg(Htr1a-icre)1Fto,
Tg(I12b-cre)1Jlr,
Tg(Icam5-cre)DYyos,
Tg(Igbp1b-cre)1Imku,
Tg(Ins2-cre)25Mgn,
Tg(INS-icre)18Msdr,
Tg(ITGAM-cre)2781Gkl,
Tg(Itgam-cre)AJva,
Tg(Kap-cre)29066/2Sig,
Tg(Kcnc2-cre)K128Stl,
Tg(Kdr-cre)15962Brei,
Tg(Kdr-cre)15964Brei,
Tg(Kit-cre)151Eks,
Tg(KRT14-cre)1Amc,
Tg(Krt15-cre/ERT2)1Johu,
Tg(KRT18-cre/ERT2)1Rgo,
Tg(Lhb-cre)1Sac,
Tg(Lhx6-cre)1Kess,
Tg(Lmx1a-cre)1Kjmi,
Tg(Mbp-cre)29Miur,
Tg(Mbp-cre)6Gvn,
Tg(Mbp-cre)9Gvn,
Tg(Mbp-cre,CAG-EGFP)53Masa,
Tg(mI56i-cre)6-2Clou,
Tg(mI56i-FLPe)39Fsh,
Tg(MMTV-cre)4Mam,
Tg(Mpz-cre)1Brn,
Tg(Mpz-cre)26Mes,
Tg(Mpz-cre)94Imeg,
Tg(Mpz-cre/ERT2)2Ueli,
Tg(Mx1-cre)29-4Her,
Tg(Myh11-cre)5013Gko,
Tg(Myh11-cre,-EGFP)2Mik,
Tg(Mylpf-cre)3Kraj,
Tg(Nefh-cre)12Kul,
Tg(Nefh-cre)22Jcol,
Tg(NEFL-cre)50Msd,
Tg(Nes-cre)1Atp,
Tg(Nes-cre)1Kag,
Tg(Nes-cre)1Kln,
Tg(Nes-cre)1Sasa,
Tg(Nes-cre)1Wme,
Tg(Nes-cre)1Wmz,
Tg(Nes-cre/ERT2)1Fsh,
Tg(Nes-cre/ERT2)1Kag,
Tg(Nes-cre/ERT2)4Kag,
Tg(Nes-cre/ERT2)5-1Kag,
Tg(Nes-cre/ERT2)73Lfp,
Tg(Nes-cre/ERT2)KEisc,
Tg(Nes-cre/Esr1*)4Ynj,
Tg(Nes-phiC31*)1Imayo,
Tg(Nes-phiC31*/ERT2)2Imayo,
Tg(Nes-phiC31*/ERT2)4Imayo,
Tg(Neurog1-cre)1Jejo,
Tg(Neurog1-cre/ERT2)1Good,
Tg(Neurog2-cre/GFP)1Stoy,
Tg(Neurog3-cre)C1Able,
Tg(Nkx2-1-cre)1Wdr,
Tg(Nkx2-1-cre)2Sand,
Tg(Nphs1-cre)1Seq,
Tg(Nr2e1-cre/ERT2)1Gsc,
Tg(Nr5a1-cre)2Klp,
Tg(Nr5a1-cre)2Lowl,
Tg(Nr5a1-cre)7Lowl,
Tg(Ntsr1-cre)GN220Gsat,
Tg(P0-Cre)1Gth,
Tg(P0-Cre)2Gth,
Tg(P0-Cre)3Gth,
Tg(Pax2-cre)1Akg,
Tg(Pax2-cre)1Amc,
Tg(Pax3-cre)1Joe,
Tg(Pax7-cre/ERT2)1Cbm,
Tg(Pcdh21-cre)BYoko,
Tg(Pcdh21-cre/ERT)CYoko,
Tg(Pcp2-cre)1Amc,
Tg(Pcp2-cre)22Lfr,
Tg(Pcp2-cre)2Mpin,
Tg(Pcp2-cre)3555Jdhu,
Tg(Pcp2-cre)756Mro,
Tg(Pcp2-cre)GN135Gsat,
Tg(Pdgfb-icre/ERT2)1Frut,
Tg(Pf4-cre)Q3Rsko,
Tg(Pitx1-cre)1Rsd,
Tg(Plp1-cre/ERT2)1Ueli,
Tg(Plp1-cre/ERT)3Pop,
Tg(Pomc1-cre)16Lowl,
Tg(Pomc1-cre)1Gsb,
Tg(Pomc-cre)1Stl,
Tg(Pou3f4-cre)32Cren,
Tg(POU3F4-cre)M51Cren,
Tg(Ppp1r1b-cre)1Meeh,
Tg(Ppp1r2-cre)4127Nkza,
Tg(Pres-cre)1Jnz,
Tg(Prnp-cre/ERT)28.4Ics,
Tg(Prph1-cre)11Dmd,
Tg(Prph1-cre)25Dmd,
Tg(Prph1-cre)35Dmd,
Tg(Pvalb-cre)1Mony,
Tg(Pvalb-cre)1Tama,
Tg(Rarb-cre)1Bhr,
Tg(REN-cre)1Haca,
Tg(Rr5-GFP/cre)1Sapc,
Tg(rtetR-tetO-cre)1Mhz,
Tg(rtetR-TetO-cre)40Mhz,
Tg(rx3-icre)1Mjam,
Tg(S100b-cre)20Ito,
Tg(S100b-EGFP/cre/ERT2)22Amc,
Tg(Scgb1a1-cre)1Grau,
Tg(Scn10a-cre)1Rkun,
Tg(Sftpa1-cre)1Xya,
Tg(Sim1-cre)1Lowl,
Tg(Six3-cre)69Frty,
Tg(Slc16a8-cre/ERT2,-EGFP)1Moss,
Tg(Slc17a6-icre)1Oki,
Tg(SLC18A3-cre)AMisa,
Tg(SLC18A3-cre)KMisa,
Tg(Slc1a3-cre/ERT2)45-72Fwp,
Tg(Slc6a2-cre)FV317Gsat,
Tg(Slc6a2-cre)FV319Gsat,
Tg(Slc6a3-cre)1Fto,
Tg(Slc6a3-cre/ERT2)1Span,
Tg(Slc6a3-icre)1Fto,
Tg(Slc6a4-cre/ERT2)EZ8Gsat,
Tg(Slc6a4-cre)ET124Gsat,
Tg(Slc6a4-cre)ET33Gsat,
Tg(Slc6a4-cre)ET35Gsat,
Tg(Slc6a5-icre)121Veul,
Tg(Slco1c1-icre/ERT2)1Mrks,
Tg(Smad7-cre)1Sjc,
Tg(Sox10-cre)507Mcln,
Tg(Sox2-cre/ERT2)1Skn,
Tg(Syn1-cre)671Jxm,
Tg(Tagln-cre)1Her,
Tg(Tal1-cre/ERT)145AJame,
Tg(Tal1-cre/ERT)1Jrg,
Tg(Tal1-cre/ERT)90Jame,
Tg(T-cre)1Lwd,
Tg(Tek-cre)5326Sato,
Tg(Tek-cre/ERT2)1Arnd,
Tg(tetO-cre)1Kdmc,
Tg(tetO-cre)1Lin,
Tg(tetO-cre)LC1Bjd,
Tg(Th-cre)12Mrub,
Tg(Th-cre)1Tmd,
Tg(Th-cre)FI12Gsat,
Tg(Th-phiC31*)1Imayo,
Tg(Thy1-cre)1Vln,
Tg(Thy1-cre)703Vaw,
Tg(Thy1-cre/PGR)1Gsc,
Tg(Tie1-cre)9Ref,
Tg(Tlx2-cre)#Mori,
Tg(Trh-cre)40Anh,
Tg(Trh-cre)5Anh,
Tg(TSPY-cre)33aYfcl,
Tg(Tuba1-cre)1Tes,
Tg(Tyr-cre)1Gfk,
Tg(Tyr-cre)1Lru,
Tg(Tyrp1-cre)1Ipc,
Tg(UBC-cre/ERT2)1Ejb,
Tg(Ure2-cre)1Jlr,
Tg(Vav1-cre)8Cgp,
Tg(Vil-cre)997Gum,
Tg(Wfs1-cre/ERT2)3Aibs,
Tg(Wnt1-cre)11Rth,
Tg(Wnt1-cre/ERT)1Alj,
Tg(Wnt1-cre/Esr1*)10Rth,
Tg(Wnt1-FLP1)1Dym,
Tg(Zic4-icre)1Kess,
Thtm1(cre/Esr1)Nat,
Thtm1(cre)Te,
Twist2tm1.1(cre)Dor,
Vamp2tm1(cre/ERT)Nat,
Viptm1(cre)Zjh,
Wnt3atm1.1(cre)Mull
(less)
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Images
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J:184579
Fig. Chat Brain 1 Adult
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Fig. Chat Brain 1 P7
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Fig. Chat Brain 2 Adult
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Fig. Chat Brain 2 P7
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Fig. Chat Embryo 1 E15.5
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Fig. Chat Embryo 2 E15.5
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Fig. Chat Periph nerve Adult
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Fig. Chat Periph Nerve P7
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Fig. Chat Sp Cord 1 Adult
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Fig. Chat Sp Cord 1 P7
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Fig. Chat Sp Cord 2 Adult
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Fig. Chat Sp Cord 2 P7
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Recombinase Activity
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Click heading to resort table.
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References
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Analysis Tools