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Chattm1(cre)Lowl - Integumental System
Recombinase Activity Detail
Allele Information
Allele:
Chattm1(cre)Lowl
choline acetyltransferase; targeted mutation 1, Bradford B Lowell 		Driver: Chat
Type: Targeted (knock-in)
Synonym: ChAT-IRES-Cre
Molecular description: An optimized internal ribosome entry sequence (IRES) fused to cre recombinase followed by a neomycin resistance cassette flanked FRT sites was inserted after the ChAT stop codon in BAC (bMQ185k21) using homologous recombination in bacteria. A genomic ChAT fragment with 4kb homology arms on either side of the IRES-Cre insertion site was lifted out from the BAC using reverse recombineering techniques and transformed into ES cells. The neo cassette was excised with Flp recombinase. Cre recombinase activity is reported in all cholinergic neurons. This allele generated from Chattm2(cre)Lowl.
Find mice (IMSR): Mouse Strains: 1 lines available       Cell Lines: 0 lines available
Additional Tissues: Chattm1(cre)Lowl activity also observed in:
alimentary system, nervous system, renal and urinary system, reproductive system, sensory organs
Tissue Information
Integumental System Other recombinase alleles with activity in Integumental System tissues:
Images
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J:184579
Fig. Chat Skin Adult J:184579
Fig. Chat Skin P7
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 14 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/22/2013
MGI 5.13 		The Jackson Laboratory