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Tg(Col2a1-cre/ERT)KA3Smac - Embryo-other
Recombinase Activity Detail
Allele Information
transgene insertion KA3, Susan Mackem
Driver: Col2a1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Col2CreERT, Tg(Col2a1-cre/ESR1)1Smac, Tg(Col2a1-cre/ESR1)KA3Smac
Molecular description: This transgene expresses a tamoxifen inducible form of cre recombinase driven by the Col2a1 promoter in cartilage. The cre recombinase coding region is joined to sequence encoding the ligand binding domain of the human estrogen receptor with a glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability.
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Col2a1-cre/ERT)KA3Smac activity also observed in:
Tissue Information
Embryo-other Other recombinase alleles with activity in Embryo-other tissues:
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J:111627 Fig. 2
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory