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Tg(Pcp2-cre)1Amc - Nervous System
Recombinase Activity Detail
Allele Information
Allele:
Tg(Pcp2-cre)1Amc
transgene insertion 1, Andrew P McMahon
Driver: Pcp2
Type: Transgenic (Recombinase)
Synonym: L7Cre, L7-Cre, L7-deltaAUG Cre
Molecular description: The transgene was generated by placing the L7-deltaAUG promoter enhancer (from the L7-deltaAUG vector in which all upstream ATGs have been mutated) upstream of cre in the pSP-13Cre plasmid. The L7/Pcp2 modified promoter can direct tissue specific expression of genes downstream of it but translation can only be initiated from the ATG of the cre gene downstream of the promoter, resulting in tissue specific expression of cre protein in cerebellar Purkinje cells. (NOTE: A GFP transgene co-integrated with the Tg(Pcp2-cre)1Amc transgene. As such, GFP expression is reported in the cerebellum [personal communication])
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Pcp2-cre)1Amc activity also observed in:
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Images
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J:137887 Fig. Pcp Brain 2 Adult J:137887 Fig. Pcp Brain Adult J:137887 Fig. Pcp Brain E15.5 J:137887 Fig. Pcp Cerebellum a P7 J:137887 Fig. Pcp Cerebellum b P7 J:137887 Fig. Pcp Cerebellum P7 J:137887 Fig. Pcp Hippocampus P7 J:137887 Fig. Pcp Midbrain Adult
J:137887 Fig. Pcp Muscle Nerve a P7 J:137887 Fig. Pcp Muscle Nerve P7 J:92189 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory