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Tg(Atoh1-cre/Esr1*)14Fsh - Nervous System
Recombinase Activity Detail
Allele Information
transgene insertion 14, Gordon Fishell
Driver: Atoh1
Type: Transgenic (Inducible, Recombinase)
Inducer: tamoxifen
Synonym: Atoh1-cre, Math1-cre, Math1-CreERT2, Tg(Atoh1-cre/ESR1)1Fsh, Tg(HBB-cre)1Fsh
Molecular description: The transgene was designed with a 1.4 kb mouse Math1 (Atoh1) 3' enhancer (and a beta-globin minimal promoter) sequence upstream of a CreERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Tamoxifen-inducible cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex).
Find mice (IMSR): Mouse Strains: 1 strain available       Cell Lines: 0 lines available
Additional Tissues: Tg(Atoh1-cre/Esr1*)14Fsh activity also observed in:
reproductive system, sensory organs
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory