Tg(Atoh1-cre/Esr1*)14Fsh - Adipose Tissue Recombinase Activity Detail MGI Mouse

Tg(Atoh1-cre/Esr1*)14Fsh - Adipose Tissue
Recombinase Activity Detail

Allele Information | Recombinase Activity | References

Allele Information

Allele:

Tg(Atoh1-cre/Esr1*)14Fsh
transgene insertion 14, Gordon Fishell

Driver: Atoh1
Type: Transgenic (Inducible, Recombinase)

Inducer:

tamoxifen

Synonym:

Atoh1-cre, Math1-cre, Math1-CreER^T2, Tg(Atoh1-cre/ESR1)1Fsh, Tg(HBB-cre)1Fsh

Molecular description:

The transgene was designed with a 1.4 kb mouse Math1 (Atoh1) 3' enhancer (and a beta-globin minimal promoter) sequence upstream of a CreERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Tamoxifen-inducible cre activity is observed in neural progenitors of the cerebellar rhombic lip, dorsal hindbrain and spinal cord, as well as in inner-ear primordia (with a limited amount of ectopic expression in the primordium of the hippocampus but not the cortex).

Find mice (IMSR):

Mouse Strains: 1 strain available Cell Lines: 0 lines available

Additional Tissues:

Tg(Atoh1-cre/Esr1*)14Fsh activity also observed in:
head, nervous system, reproductive system, sensory organs

Recombinase Activity

Click heading to re-sort table.

Assays Genotypic Background Result Notes

References

All for this allele:

67 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23