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Tg(Gnrh1-cre)1Rsp - Nervous System
Recombinase Activity Detail
Allele Information
transgene insertion 1, Rolf Sprengel
Driver: Gnrh1
Type: Transgenic (Recombinase)
Synonym: TgGnRH-iCre
Molecular description: The mouse gonadotropin-releasing hormone promoter was used to drive the expression of improved cre (icre). The icre was assembled from oligonucleotides to introduce silent base mutations corresponding to human codon-usage preferences, minimize CpG content, eliminate putative cryptic splice sites and alter the stop codon. Cre activity was detected in 97% of Gnrh immunopositive neurons and in a second population of cells, mainly the limbic system neurons. Four lines exhibiting high expression and three with low expression were obtained. This is a representative from those lines.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Tissue Information
Nervous System Other recombinase alleles with activity in Nervous System tissues:
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J:78663 Fig. 4
Recombinase Activity
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Assays Genotypic Background Result Notes  
All for this allele: 2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.03
The Jackson Laboratory