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Isl1tm1(cre/Esr1*)Krc - Cardiovascular System
Recombinase Activity Detail
Allele Information
Allele:
Isl1tm1(cre/Esr1*)Krc
ISL1 transcription factor, LIM/homeodomain; targeted mutation 1, Kenneth R Chien
Driver: Isl1
Type: Targeted (Inducible, Recombinase)
Inducer: induced by tamoxifen
Synonym: isl1-MCM, isl1-mER-Cre-mER, isl1-MerCreMer, Isl1tm1(cre/Esr1)Krc, MerCreMer
Molecular description: A targeting cassette containing a tamoxifen-dependent cre flanked by two mutated mouse estrogen receptors that sequester cre to the cytoplasm, followed by an FRT-flanked neo was inserted into the Isl1 locus by homologous recombination. A short segment of coding region containing the endogenous ATG codon was deleted.
Find mice (IMSR): Mouse Strains: 0 strains available       Cell Lines: 0 lines available
Additional Tissues: Isl1tm1(cre/Esr1*)Krc activity also observed in:
embryo-other, nervous system
Tissue Information
Cardiovascular System Other recombinase alleles with activity in Cardiovascular System tissues:
Images
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J:96092 Fig. 3
Recombinase Activity
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Assays Genotypic Background Result Notes  
References
All for this allele: 11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/02/2014
MGI 5.19
The Jackson Laboratory